To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation.
Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60°C and the acoustic energy for increasing 1°C of temperature at the single point before and after using oxytocin were compared.
Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (5320 ± 910) J and it took (21 ± 20) seconds for sonicating a single point, the energy required for increasing 1°C was (255 ± 302) J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (2890 ± 325) J, and it took (12 ± 7) seconds for sonicating a single point, the energy required for increasing 1°C was (126 ± 94) J. Those three index all reached statistical difference (P = 0.002, P = 0.001, P = 0.002, respectively).
It seemed that Oxytocin could significantly decrease the energy required for ablating uterine fibroids, shorten treatment time and improve the treatment efficiency.
PMID: 21781579 [PubMed – indexed for MEDLINE]
Oxytocin increases the receptiveness of cells to external stimuli. Thus, this may increase their reception to sonic energies through a variety of mechanisms.
Stop using ultrasound to determine sex of fetuses, urge doctors, radiologists
“Canada’s pregnancy specialists and the nation’s radiologists are calling for a halt on using ultrasound for the sole purpose of determining the sex of an unborn fetus.
In a new joint policy statement, the Society of Obstetricians and Gynaecologists of Canada and the Canadian Association of Radiologists also say it could be considered unethical for private, commercial clinics to offer “entertainment” ultrasounds purely for the purpose of creating “keepsake” videos for expectant parents.
The position statement comes amid mounting concerns that in Canada, people are using ultrasound to determine the sex of a fetus early in pregnancy and to have it aborted if it is a girl.”
This just goes to show that ultrasound will soon be used to enhance the treatment of a variety of diseases. Metabolic disorders and neuropathology, too.
The overall prognosis for malignant glioma is extremely poor, and treatment options are limited in part because of multidrug resistant proteins. Our previous findings suggest low intensity ultrasound (LIUS) can induce apoptosis of glioma cells. Given this finding, we were interested in determining if LIUS could help treat glioma by inhibiting multidrug resistant proteins, and if so, which pathways are involved. In this study, the toxicity sensitivity and multidrug resistance proteins of glioma induced by LIUS were investigated using CCK-8, immunohistochemistry, immunofluorency, and RT-PCR in tissue samples and cultured cells. LIUS inhibited increase of C6 cells in an intensity- and time-dependent manner. The toxicity sensitivity of C6 cells increased significantly after LIUS sonication (intensity of 142.0 mW/cm2) or Doxorubicin (DOX) at different concentration, particularly by the combination of LIUS sonication and DOX. The expressions of P-gp and MRP1 decreased significantly post-sonication at intensity of 142.0 mW/cm2 both in vitro and in vivo. The expressions of p110 delta (PI3K), NF-κB-p65, Akt/PKB, and p-Akt/PKB were downregulated by LIUS sonication and DOX treatment separately or in combination at the same parameters in rat glioma. These results indicate that LIUS could increase the toxicity sensitivity of glioma by down-regulating the expressions of P-gp and MRP1, which might be mediated by the PI3K/Akt/NF-κB pathway.
A survey in 2006 found that only 3.8% of sonographers could correctly explain the safety readout on an ultrasound machine. This is unacceptable.
Watch this video to learn more about shortcomings in sonographer education worldwide. This is important if you plan on having children any time soon.
A few years ago, a 12 year old girl was admitted to a hospital for heart murmurs. A defective ultrasound transducer was used and they could not detect why the murmurs occurred. Repeating this procedure (nearly 2 years later) with a different machine showed dramatically different results.
This prompted a study in which 32 hospitals were censused for the efficacy of their ultrasound units. 39.8% of transducers were found defective.
Sonographers cannot tell when a transducer is defective intuitively, it just makes the picture worse. Oftentimes they will compensate by turning up the power to get a more clear image. Ob-Gyn ultrasound suffers the same problem, and this will expose our children to unnecessarily high intensities.
Watch the video to learn more –
Prenatal sonography – the urgent need for more research and better regulation
Despite ultrasound being utilized in nearly every modern pregnancy, its safety is highly questionable. Many parents are told that ultrasound is completely safe, but this is not science fact. The unfortunate truth is that no sonographer or doctor knows what ultrasound exposure will do to your baby — they can’t, no scientist fully understands yet.
This petition was written as an attempt to raise awareness of this issue and to gather people together. Shortcomings in safety regulation are just one part of a greater combination of problems with obstetrical care. It seems like women are losing control of their pregnancies more and more, and money seems to lead modern practice more than conservative methods to ensure patient safety. Practitioners receive more pay in exchange for encouraging patients to receive more treatments than absolutely necessary.
Today was a landmark day for our petition. We raised nearing 500 signatures in a single day. Thank you, everybody. If you have not, please sign and share:
Dr. Sarah Buckley, MD, created this website back in 2005. To summarize: studies estimate 99% of Australians, 70% of North American pregnancies involve prenatal ultrasound…why? It is very risky. Using it as a screening tool for abnormalities is exposing a majority of the population and this is dangerous.
I agree.. it’s a problem that is mostly propagated because of business success. Every individual mother is going to want baby pictures, making it a viral market. With the advent of social media pictures are self advertising treasures.
Yet, not enough research has been done to prove that they are safe yet. Research takes a lot of time, especially when there is no fountain of money just waiting.
There have been many side effects discovered in animal models, but ethics issues preclude human studies. So the safety assessments released have concluded safety based on lack of evidence.
The side effects discovered already urgently demand further attention… more research is required. Consider reblogging this message because more people need to know about these risks. Apparently the message didn’t get out in 2005.
Our future generation’s health is seriously called to question here.